Gemsitabin Salımı için Kitosan/κ-Karajenan Temelli Polimerik Nanopartiküllerin Sentezi ve Karakterizasyonu

Cancer is the most fatal disease of last century after cardiovascular disease. Gemcitabine a nucleosideanalogue used in treatment cancer. However, like many anticancer drugs, it has side effects thatlimit treatment. A nano drug delivery system been developed to provide effective by reducingside effects. Chitosan and κ-carrageenan, which are regarded as safe FDA, were preparationof system. In synthesis, pre-ionic gelation followed polyelectrolyte complexationmethod was then second ionic step added. Chitosan: κ-carrageenan ratio CaCl2concentration optimized optimum polymer determined 6:1 CaCl2 concentrationwas 2.5%. Its hydrodynamic size at conditions 393 nm its measured TEM 20nm. FTIR analyzes showed that nanoparticle synthesis successful. Drug loading performed byencapsulation 58% achieved. After loading, dimension wasincreased 595 45 nm. release monitored for 95 hours andwas be higher pH 6.0 compared 7.4 sensitive. addition, Higuchi model themost suitable mathematical kinetics. The obtained results chitosan: κcarrageenan nanoparticles gemcitabine sensitive enough respond tothe tumor microenvironment.